An article published in the NEUROLOGY journal in 2012 points to a link between parental migraine and colic in babies. Parents suffering from migraines were more likely to have babies with colic. Migraine, just like colic is likely triggered by vasoactive substances present in the body in unbalanced quantities. In some adults, migraine manifests in not just a severe headache, but also in abdominal cramping - just what appears to be happening in colic babies. This article indirectly supports the use of vasoactive compounds, such as anethole, a component of fennel seed oil, used to formulate Pediacalm, colic remedy from Lev Laboratories, to treat baby colic.